a beneficial Tertile cutoffs to own plasma folate density were for men, 5.8 and nine.5 nmol/L; and female, six.1 and you may 10.seven nmol/L.
During the Desk step 3, heterogeneity is actually investigated within the subgroups considering intercourse, age, follow-up time taken between standard and you may colorectal cancer tumors analysis, tumefaction website, tumor stage, and you will cohort
c Tertile cutoffs for plasma nutritional B12 concentrations was indeed for males, 352 and 456 pmol/L; and for ladies, 370 and you can 480 pmol/L.
d Tertile cutoffs to have plasma total homocysteine density was for men, 9.step three and you can eleven.4 ?mol/L; as well as female, 8.5 and you can 10.6 ?mol/L.
For plasma folate concentrations, the same distribution of OR for colorectal cancer was observed in most subgroups as in the full study group, with the exception of follow-up time above the median, rectal tumor localization, and stage I–II, for which associations were essentially null. Low plasma folate concentrations were associated with a reduced colorectal cancer risk in subjects with follow-up times below the median of 10.8 years, OR 2.49 (95% CI, 1.33–4.64) for the middle versus lowest tertile and OR 2.43 (95% CI, 1.27–4.65) for the highest versus lowest tertile. A positive risk relationship was observed for tumor stage III–IV but not I–II [multivariate OR for stage III–IV, middle versus lowest tertile of plasma folate concentrations, 2.51 (95% CI, 1.37–4.63)].